Changes in Hepatic Enzyme Activities Related to Ethanol Metabolism in Mice Following Chronic Ethanol Administration.
نویسندگان
چکیده
منابع مشابه
Adaptive Changes Induced by Chronic Ethanol Ingestion on Hepatic Mitochondrial and Microsomal Enzyme Activities
Ethanol exerts its pbarmacologlcal effects by alteriag the pkysico-ckemical propeof biological membranes. Modlflcatlons induced by ethanol may reta& in ckangeg lo the activity of membtane-boand enzymes tkat have been shown to reqdre a speclflc membram? flnldlty and composition for optimal function. In tbll study we have carried oat the analysis of the effects of ethanol on the different enzyme ...
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Mitochondrial protein acetylation increases in response to chronic ethanol ingestion in mice, and is thought to reduce mitochondrial function and contribute to the pathogenesis of alcoholic liver disease. The mitochondrial deacetylase SIRT3 regulates the acetylation status of several mitochondrial proteins, including those involved in ethanol metabolism. The newly discovered desuccinylase activ...
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The effect of an acute oral load of 2 g ethanol/kg body weight was studied in a group of male and female 10-wk-old C3H/HeNCrj (C3H/He) mice to investigate gender change throughout differences of the hepatic ethanol metabolism of mice. The following parameters were measured in the serum from 0 h to 3 h after the start of the experiment: ethanol, acetaldehyde, and acetate. Their concentrations in...
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BACKGROUND/AIMS An increase of ethanol metabolism and hepatic mitochondrial respiration occurs in vivo after a single binge of alcohol. Here, our aim was to determine how ethanol intake affects hepatic mitochondrial polarization status in vivo in relation to ethanol metabolism and steatosis. METHODS Hepatic mitochondrial polarization, permeability transition (MPT), and reduce pyridine nucleot...
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ژورنال
عنوان ژورنال: Journal of Nutritional Science and Vitaminology
سال: 1995
ISSN: 0301-4800,1881-7742
DOI: 10.3177/jnsv.41.527